GDC-0310


Catalog No. Size PriceQuantity
M26860-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Product information

CAS Number: 1788063-52-4

Molecular Weight: 543.48

Formula: C25H29Cl2FN2O4S

Chemical Name: 5-cyclopropyl-4-({1-[(1S)-1-(3,5-dichlorophenyl)ethyl]piperidin-4-yl}methoxy)-2-fluoro-N-methanesulfonylbenzamide

Smiles: C[C@@H](C1C=C(Cl)C=C(Cl)C=1)N1CCC(COC2=CC(F)=C(C=C2C2CC2)C(=O)NS(C)(=O)=O)CC1

InChiKey: SXOAHIZWCZOILH-HNNXBMFYSA-N

InChi: InChI=1S/C25H29Cl2FN2O4S/c1-15(18-9-19(26)11-20(27)10-18)30-7-5-16(6-8-30)14-34-24-13-23(28)22(12-21(24)17-3-4-17)25(31)29-35(2,32)33/h9-13,15-17H,3-8,14H2,1-2H3,(H,29,31)/t15-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

GDC-0310 exhibits an EC50 of 1.1 μM in vivo and a Ki of 1.8 nM for Nav1.7.

In Vivo:

GDC-0310 shows substantially improved Nav selectivity and ADME properties. GDC-0310 exhibits t1/2 values of 5 h, 46 h and 4.4 h in rat (5 mg/kg, iv), dog (1 mg/kg, iv) and cynomolgus monkeys (2 mg/kg, iv), respectively.

Products are for research use only. Not for human use.

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