Methenamine hippurate

Methenamine hippurate (Hexamine hippurate) is an orally active urinary antiseptic agent with a wide antibacterial spectrum. Methenamine hippurate is effective against most common urinary tract pathogens.

Product information

CAS Number: 5714-73-8

Molecular Weight: 319.36

Formula: C15H21N5O3

Chemical Name: 1,3,5,7-tetraazatricyclo[3.3.1.1³,⁷]decane; 2-(phenylformamido)acetic acid

Smiles: OC(=O)CNC(=O)C1C=CC=CC=1.C1N2CN3CN1CN(C2)C3

InChiKey: ROAIXOJGRFKICW-UHFFFAOYSA-N

InChi: InChI=1S/C9H9NO3.C6H12N4/c11-8(12)6-10-9(13)7-4-2-1-3-5-7;1-7-2-9-4-8(1)5-10(3-7)6-9/h1-5H,6H2,(H,10,13)(H,11,12);1-6H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 25 mg/mL (78.28 mM; Need ultrasonic). H2O : 100 mg/mL (313.13 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Methenamine hippurate is a urinary antibacterial agent which releases formaldehyde and is excreted in the urine. Methenamine hippurate has a demonstrable activity in vitro at pH 5 to 6 against Escherichia coli, Staphylococcus aureus, Aerobacter aeroaenes, Pseudomonas aeruginosa and Proteus vulgaris, and a wide range of action against Klebsiella pneumoniae, Ps. aeruginosa, E. coli, Staph. aureus and Streptococcus haemolytic at pH of 7.4. This action is more effective than that of Methenamine alone, of Hippuric acid alone or of Sulphadiazine.

Products are for research use only. Not for human use.