Allergen Gal d 4 (46-61), chicken

Allergen Gal d 4 (46-61), chicken is a hen egg white lysozyme peptide.

Product information

CAS Number: 62982-31-4

Molecular Weight: 1753.82

Formula: C72H116N22O29

Chemical Name: (2S)-2-[(2S)-2-[(2S)-2-[(2S,3S)-2-[(2S)-2-[(2S)-2-[(2S,3S)-2-{2-[(2S)-2-[(2S)-2-[(2S,3R)-2-[(2S)-2-{2-[(2S)-2-[(2S,3R)-2-[(2S)-2-amino-3-carbamoylpropanamido]-3-hydroxybutanamido]-3-carboxypropanamido]acetamido}-3-hydroxypropanamido]-3-hydroxybutanamido]-3-carboxypropanamido]-3-(4-hydroxyphenyl)propanamido]acetamido}-3-methylpentanamido]-4-methylpentanamido]-4-carbamoylbutanamido]-3-methylpentanamido]-3-carbamoylpropanamido]-3-hydroxypropanamido]-5-carbamimidamidopentanoic acid

Smiles: CC(C)C[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(N)=O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

InChiKey: HYXXBINWGPYLTQ-DMWLTYJSSA-N

InChi: InChI=1S/C72H116N22O29/c1-9-31(5)54(67(118)86-40(20-30(3)4)62(113)83-38(17-18-47(74)100)61(112)92-55(32(6)10-2)68(119)87-42(23-49(76)102)63(114)90-46(29-96)65(116)84-39(71(122)123)12-11-19-79-72(77)78)91-51(104)27-81-59(110)41(21-35-13-15-36(99)16-14-35)85-64(115)44(25-53(107)108)89-70(121)57(34(8)98)94-66(117)45(28-95)82-50(103)26-80-60(111)43(24-52(105)106)88-69(120)56(33(7)97)93-58(109)37(73)22-48(75)101/h13-16,30-34,37-46,54-57,95-99H,9-12,17-29,73H2,1-8H3,(H2,74,100)(H2,75,101)(H2,76,102)(H,80,111)(H,81,110)(H,82,103)(H,83,113)(H,84,116)(H,85,115)(H,86,118)(H,87,119)(H,88,120)(H,89,121)(H,90,114)(H,91,104)(H,92,112)(H,93,109)(H,94,117)(H,105,106)(H,107,108)(H,122,123)(H4,77,78,79)/t31-,32-,33+,34+,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,54-,55-,56-,57-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Allergen Gal d 4 (46-61), chicken (HEL(46-61)) contains the immunodominant epitope recognized by mice of the k haplotype. The binding is shown to be specific, with a Kd of approximately 2 uM. The direct binding of a hen egg white lysozyme peptide, Allergen Gal d 4 (46-61), is examined to membrane I-Ak (protein encoded in the A locus of the I region) molecules in the presence of detergent. A number of synthetic peptide derivatives, which do not stimulate our T-cell reactive hybridomas, compete for the binding of Allergen Gal d 4 (46-61) to I-Ak and also inhibit the functional presentation of Allergen Gal d 4 (46-61). Inhibitors include a peptide lacking a tyrosine at position 53 and a peptide corresponding to the autologous lysozyme peptide. Presentation is examined with cells or with supported planar phospholipid membranes bearing only I-Ak and Allergen Gal d 4 (46-61).

Products are for research use only. Not for human use.