Description
FGI-106 tetrahydrochloride is a potent and broad-spectrum inhibitor with inhibitory activity against multiple viruses. FGI-106 tetrahydrochloride is active against Ebola, Rift Valley and Dengue Fever viruses with EC50s of 100 nM, 800 nM and 400-900 nM, respectively. FGI-106 tetrahydrochloride also inhibits non-hemorrhagic fever viruses HCV and HIV-1 with EC50s of 200 nM and 150 nM, respectively.
Product information
CAS Number: 1149348-10-6
Molecular Weight: 604.49
Formula: C28H42Cl4N6
Chemical Name: N6,N15-bis[3-(dimethylamino)propyl]-4,13-dimethyl-3,12-diazatetracyclo[8.8.0.0²,⁷.0¹¹,¹⁶]octadeca-1,3,5,7,9,11(16),12,14,17-nonaene-6,15-diamine tetrahydrochloride
Smiles: Cl.Cl.Cl.Cl.CN(C)CCCNC1=CC(C)=NC2C3=CC=C4C(N=C(C)C=C4NCCCN(C)C)=C3C=CC1=2
InChiKey: YUQCVPFHAFZFPV-UHFFFAOYSA-N
InChi: InChI=1S/C28H38N6.4ClH/c1-19-17-25(29-13-7-15-33(3)4)23-11-10-22-21(27(23)31-19)9-12-24-26(18-20(2)32-28(22)24)30-14-8-16-34(5)6;;;;/h9-12,17-18H,7-8,13-16H2,1-6H3,(H,29,31)(H,30,32);4*1H
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 6.67 mg/mL (11.03 mM; ultrasonic and warming and adjust pH to 2 with HCl and heat to 60°C).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Treatment with 2 μM FGI-106 mediated a 4 log reduction in infectious viral titers relative to matched controls, with an EC90 for inhibition of viral killing of host cells (Vero E6 cells) estimated to be 0.6 μM. In cell-based assays, treatment with FGI-106 inhibits viral replication by divergent virus families, including positive and negative-strand RNA viruses.
In Vivo:
FGI-106 (0.1-5 mg/kg; intraperitoneal injection; treatments on days 2 and 5; C57BL/6 or BALB/c mice) treatment decreases mortality from Zaire EBOV in a dose-dependent manner.
Products are for research use only. Not for human use.
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