Description
PF-02575799 is a microsomal triglyceride transfer protein (MTP) inhibitor with an IC50 of 0.77±0.29 nM.
Product information
CAS Number: 863491-70-7
Molecular Weight: 680.77
Formula: C42H37FN4O4
Chemical Name: N-(6-{[(S)-{[(4-fluorophenyl)methyl](methyl)carbamoyl}(phenyl)methyl]carbamoyl}quinolin-2-yl)-4'-(propan-2-yloxy)-[1,1'-biphenyl]-2-carboxamide
Smiles: CC(C)OC1C=CC(=CC=1)C1=CC=CC=C1C(=O)NC1=CC=C2C=C(C=CC2=N1)C(=O)N[C@@H](C1C=CC=CC=1)C(=O)N(C)CC1C=CC(F)=CC=1
InChiKey: HMTLPJFACYNTHS-KDXMTYKHSA-N
InChi: InChI=1S/C42H37FN4O4/c1-27(2)51-34-21-15-29(16-22-34)35-11-7-8-12-36(35)41(49)45-38-24-18-31-25-32(17-23-37(31)44-38)40(48)46-39(30-9-5-4-6-10-30)42(50)47(3)26-28-13-19-33(43)20-14-28/h4-25,27,39H,26H2,1-3H3,(H,46,48)(H,44,45,49)/t39-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PF-02575799 is compound 13 from the reference.
In Vivo:
PF-02575799 produces appreciable triglyceride effects at its minimally effective dose (10 mg/kg). PF-02575799 significant increase alanine transaminase at 100 mg/kg.
Products are for research use only. Not for human use.
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