EZ-482


Catalog No. Size PriceQuantity
M27210-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

EZ-482, a novel ligand of apolipoprotein (apoE), binds to sites on apoE in the C-terminal domain with Kds of 5-10 μM for apoE3 and apoE4. EZ-482 binds to apoE4 by a unique N-terminal allosteric effect. EZ482 has the potential for Alzheimer’s diseas.

Product information

CAS Number: 1016456-76-0

Molecular Weight: 498.94

Formula: C23H19ClN4O5S

Chemical Name: N-{5-[(3-chlorophenyl)sulfamoyl]-2-hydroxyphenyl}-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetamide

Smiles: CN1N=C(CC(=O)NC2=CC(=CC=C2O)S(=O)(=O)NC2=CC(Cl)=CC=C2)C2=CC=CC=C2C1=O

InChiKey: CLWDCBBEVQRZLY-UHFFFAOYSA-N

InChi: InChI=1S/C23H19ClN4O5S/c1-28-23(31)18-8-3-2-7-17(18)19(26-28)13-22(30)25-20-12-16(9-10-21(20)29)34(32,33)27-15-6-4-5-14(24)11-15/h2-12,27,29H,13H2,1H3,(H,25,30)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 83.33 mg/mL (167.01 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

EZ-482 binds to sites on apoE in the C-terminal domain encompassing residues 229-243 and 258-265. EZ-482 (0.5, 1, 5, 10 μM; 1 hour) blocks heparin binding in a concentration-dependent manner.

Products are for research use only. Not for human use.

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