Description
DFP00173 is a potent and selective aquaporin-3 (AQP3) inhibitor. DFP00173 inhibits mouse and human AQP3 with an IC50 of ∼0.1-0.4 μM. DFP00173 is selective for AQP3 over the homologous AQP isoforms AQP7 and AQP9.
Product information
CAS Number: 672286-03-2
Molecular Weight: 332.16
Formula: C11H7Cl2N3O3S
Chemical Name: 1-(2,6-dichlorophenyl)-3-(5-nitrothiophen-3-yl)urea
Smiles: [O-][N+](=O)C1=CC(=CS1)NC(=O)NC1C(Cl)=CC=CC=1Cl
InChiKey: AATXXTHMITUAOJ-UHFFFAOYSA-N
InChi: InChI=1S/C11H7Cl2N3O3S/c12-7-2-1-3-8(13)10(7)15-11(17)14-6-4-9(16(18)19)20-5-6/h1-5H,(H2,14,15,17)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 125 mg/mL (376.32 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
DFP00173 inhibits the glycerol permeability of human erythrocytes with an IC50 of ~0.2 µM.
Products are for research use only. Not for human use.
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