KL044


Catalog No. Size PriceQuantity
M27320-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

KL044, a stabilizer of the clock protein cryptochrome (CRY) , is a potent chemical probe with a pEC50 value of 7.32, leading to the extension of the circadian period and repression of Per2 activity.

Product information

CAS Number: 1801856-93-8

Molecular Weight: 359.81

Formula: C21H14ClN3O

Chemical Name: 2-(9H-carbazol-9-yl)-N-(2-chloro-6-cyanophenyl)acetamide

Smiles: N#CC1=CC=CC(Cl)=C1NC(=O)CN1C2=CC=CC=C2C2=CC=CC=C12

InChiKey: ZDAKKNHUWVTCRS-UHFFFAOYSA-N

InChi: InChI=1S/C21H14ClN3O/c22-17-9-5-6-14(12-23)21(17)24-20(26)13-25-18-10-3-1-7-15(18)16-8-2-4-11-19(16)25/h1-11H,13H2,(H,24,26)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (277.92 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

KL044 (0-3.7 μM; 8 h) effectively stabilizes the CRY1-LUC fusion protein without affecting the stability of LUC in the HEK293 stable cell line.

Products are for research use only. Not for human use.

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