Description
SCH00013 is a cardiotonic agent that primarily acts via an increase in myofibrillar Ca++ sensitivity, have a significant Ca(2+)sensitizing effect at pH 7.2 to 7.4.In vitro: SCH00013 at 10-4 M increased the systolic cell shortening by 52% above the base-line value in association with an insignificant increase in the systolic fluorescence ratio by 15% above the control. In vivo: The positive inotropic effects of 10 4 M SCH00013 on the dog and rabbit were 38% and 29% of the maximal response to isoproterenol. CH00013 elicited a positive inotropic effect at more than 0.3 and 1 mg/kg, i.v. in normal and heart failure dogs. SCH00013 elicits a positive inotropic effect mainly through an increase in myofilament Ca2+ sensitivity without increasing the heart rate.
Product information
CAS Number: 217963-18-3
Molecular Weight: 324.38
Formula: C18H20N4O2
Chemical Name: 4-{1-hydroxy-2-[4-(6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)-1,2,3,6-tetrahydropyridin-1-yl]ethyl}benzonitrile
Smiles: N#CC1C=CC(=CC=1)C(O)CN1CC=C(CC1)C1CCC(=O)NN=1
InChiKey: BPEKLIDKLJZYOX-UHFFFAOYSA-N
InChi: InChI=1S/C18H20N4O2/c19-11-13-1-3-15(4-2-13)17(23)12-22-9-7-14(8-10-22)16-5-6-18(24)21-20-16/h1-4,7,17,23H,5-6,8-10,12H2,(H,21,24)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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