Description
I-191 is a potent, selective protease-activated receptor 2 (PAR2) antagonist.
Product information
CAS Number: 1690172-25-8
Molecular Weight: 423.48
Formula: C23H26FN5O2
Chemical Name: 4-[8-tert-butyl-6-(4-fluorophenyl)imidazo[1,2-b]pyridazine-2-carbonyl]-3,3-dimethylpiperazin-2-one
Smiles: CC(C)(C)C1=CC(=NN2C=C(N=C21)C(=O)N1CCNC(=O)C1(C)C)C1C=CC(F)=CC=1
InChiKey: DTASTQAQBOZSRR-UHFFFAOYSA-N
InChi: InChI=1S/C23H26FN5O2/c1-22(2,3)16-12-17(14-6-8-15(24)9-7-14)27-29-13-18(26-19(16)29)20(30)28-11-10-25-21(31)23(28,4)5/h6-9,12-13H,10-11H2,1-5H3,(H,25,31)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 8.33 mg/mL (19.67 mM; Need ultrasonic). H2O : < 0.1 mg/mL (insoluble).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
I-191 inhibits cytokine production as well as cytokine-related caspase cleavages via ERK1/2 signaling in HT29 colon cancer cells.
Products are for research use only. Not for human use.
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