Description
IM156 (HL156A; HL271 acetate), a chemical derivative of Metformin (HY-B0627), is a potent and orally active AMPK activator that increases AMPK phosphorylation. IM156 attenuates aging-associated cognitive impairment in animal model. IM156 is a potent oxidative phosphorylation (OXPHOS) inhibitor which can be used for the research of solid tumors.
Product information
CAS Number: 1422365-94-3
Molecular Weight: 315.29
Formula: C13H16F3N5O
Chemical Name: (E)-N-[amino(pyrrolidin-1-yl)methylidene]-N''-[4-(trifluoromethoxy)phenyl]guanidine
Smiles: NC(/N=C(\N)/N1CCCC1)=NC1C=CC(=CC=1)OC(F)(F)F
InChiKey: NGFUHJWVBKTNOE-UHFFFAOYSA-N
InChi: InChI=1S/C13H16F3N5O/c14-13(15,16)22-10-5-3-9(4-6-10)19-11(17)20-12(18)21-7-1-2-8-21/h3-6H,1-2,7-8H2,(H4,17,18,19,20)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 100 mg/mL (266.42 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
IM156 (0.31-10 μM) phosphorylates AMPKα1 Thr172 in a dose- and time-dependent manner in NIH3T3 mouse fibroblast cells. IM156 does not affect the expression of key factors involved in glucose homeostasis such as glucose-6-phosphatase (G6pase) or phosphoenolpyruvate carboxykinase 1 (Pck1).
In Vivo:
IM156 does not affect metabolic regulation assessed by body weight, blood glucose, insulin levels and lipid metabolite content in mice with diet-induced obesity. IM156 (50 mg/kg; for 2 months) does not affect body weight, general locomotion, or anxiety. IM156 significantly attenuates the aging-induced decline in novel object recognition memory and spatial working memory. IM156 significantly increases AMPK activation in the hippocampus of aged mice.
Products are for research use only. Not for human use.
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