Description
COH-SR4 is an AMPK activator. COH-SR4 shows potent anti-proliferative activities against leukemia, melanoma, breast and lung cancers. COH-SR4 inhibits adipocyte differentiation via AMPK activation. COH-SR4 can be used for the research of obesity and related metabolic disorders.
Product information
CAS Number: 73439-19-7
Molecular Weight: 350.03
Formula: C13H8Cl4N2O
Chemical Name: 1,3-bis(3,5-dichlorophenyl)urea
Smiles: O=C(NC1=CC(Cl)=CC(Cl)=C1)NC1=CC(Cl)=CC(Cl)=C1
InChiKey: VKVJIWVUYNTBEZ-UHFFFAOYSA-N
InChi: InChI=1S/C13H8Cl4N2O/c14-7-1-8(15)4-11(3-7)18-13(20)19-12-5-9(16)2-10(17)6-12/h1-6H,(H2,18,19,20)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 125 mg/mL (357.11 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
COH-SR4 (1-5 μM; 24 hours) results in a dose-dependent increase in the phosphorylation of AMPK and its substrate ACC in 3T3-L1 preadipocytes, as well as in cancer cells such as HL-60, HeLa, MCF-7. COH-SR4 (3-5 µM; 7 days) significantly inhibits 3T3-L1 adipocyte differentiation in a dose-dependent manner. COH-SR4 (1-5 μM; 24 hours) promotes cell G1 cycle arrest. COH-SR4 significantly reduces intracellular lipid accumulation and downregulates the expression of key adipogenesis-related transcription factors and lipogenic proteins.
In Vivo:
COH-SR4 (5 mg/kg; i.g.; 3x/week; for 6 weeks) reduces body weight and fat mass in high fat diet (HFD) obese mice without affecting food intake. COH-SR4 improves glycemic control and dyslipidemia in HFD obese mice. COH-SR4 decreases adipose tissue hypertrophy and affects circulating adipokine levels in HFD obese mice. COH-SR4 prevents hepatic lipid accumulation and fatty liver in HFD obese mice.
Products are for research use only. Not for human use.
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