Description
BMVC-8C3O is a DNA G-quadruplexe (G4) ligand which can induce topological conversion of non-parallel to parallel forms in human telomeric DNA G4s.
Product information
CAS Number: 1301708-12-2
Molecular Weight: 1042.61
Formula: C42H53I3N4O3
Chemical Name: 1-methyl-4-[(E)-2-{9-[2-(2-{2-[2-(1-methylpiperidin-1-ium-1-yl)ethoxy]ethoxy}ethoxy)ethyl]-6-[(E)-2-(1-methylpyridin-1-ium-4-yl)ethenyl]-9H-carbazol-3-yl}ethenyl]pyridin-1-ium triiodide
Smiles: [I-].[I-].[I-].C[N+]1(CCOCCOCCOCCN2C3=CC=C(C=C3C3=CC(/C=C/C4C=C[N+](C)=CC=4)=CC=C23)/C=C/C2C=C[N+](C)=CC=2)CCCCC1
InChiKey: DKMJOQQQBQBOMV-UHFFFAOYSA-K
InChi: InChI=1S/C42H53N4O3.3HI/c1-43-19-15-35(16-20-43)7-9-37-11-13-41-39(33-37)40-34-38(10-8-36-17-21-44(2)22-18-36)12-14-42(40)45(41)23-27-47-29-31-49-32-30-48-28-26-46(3)24-5-4-6-25-46;;;/h7-22,33-34H,4-6,23-32H2,1-3H3;3*1H/q+3;;;/p-3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 62.5 mg/mL (59.95 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
BMVC-8C3O induces topological conversion of Tel23 from a hybrid-I G4 to a parallel G4 in K+solution. BMVC-8C3O binding can induce topological changes of different non-parallel human telomeric G4s into the same parallel topology.
Products are for research use only. Not for human use.
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