Description
SHP836 is a SHP2 allosteric inhibitor, with an IC50 of 12 μM for the full length SHP2.
Product information
CAS Number: 1957276-35-5
Molecular Weight: 352.26
Formula: C16H19Cl2N5
Chemical Name: 5-(2,3-dichlorophenyl)-2-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyrimidin-4-amine
Smiles: C[C@@H]1CN(C[C@H](C)N1)C1=NC(N)=C(C=N1)C1=CC=CC(Cl)=C1Cl
InChiKey: SKFRRNOLFFQBQU-AOOOYVTPSA-N
InChi: InChI=1S/C16H19Cl2N5/c1-9-7-23(8-10(2)21-9)16-20-6-12(15(19)22-16)11-4-3-5-13(17)14(11)18/h3-6,9-10,21H,7-8H2,1-2H3,(H2,19,20,22)/t9-,10+
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 250 mg/mL (709.70 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
SHP836 stabilizes the active conformation of SHP2, in which the catalytic site is blocked and no longer accessible to substrate.
Products are for research use only. Not for human use.
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