Simotinib


Catalog No. Size PriceQuantity
M27715-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Simotinib is a selective, specific, and orally bioavailable EGFR tyrosine kinase inhibitor, with an IC50 of 19.9 nM. Antineoplastic activities.

Product information

CAS Number: 944258-89-3

Molecular Weight: 500.95

Formula: C25H26ClFN4O4

Chemical Name: N-(3-chloro-4-fluorophenyl)-6-(2-{5,8-dioxa-10-azadispiro[2.0.4⁴.3³]undecan-10-yl}ethoxy)-7-methoxyquinazolin-4-amine

Smiles: COC1=CC2=NC=NC(NC3=CC(Cl)=C(F)C=C3)=C2C=C1OCCN1CC2(CC2)C2(C1)OCCO2

InChiKey: OXWUWXCJDBRCCG-UHFFFAOYSA-N

InChi: InChI=1S/C25H26ClFN4O4/c1-32-21-12-20-17(23(29-15-28-20)30-16-2-3-19(27)18(26)10-16)11-22(21)33-7-6-31-13-24(4-5-24)25(14-31)34-8-9-35-25/h2-3,10-12,15H,4-9,13-14H2,1H3,(H,28,29,30)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Simotinib inhibits in a dose-dependent manner EGFR and the growth of human A431 tumor cells with high expression of EGFR, with no significant activity on other investigated kinases.

In Vivo:

Simotinib has been shown to exert its antitumor activity by inhibiting EGFR phosphorylation in nude xenograft model.

Products are for research use only. Not for human use.

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