DS-1971a


Catalog No. Size PriceQuantity
M27779-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

DS-1971a is a potent, selective, and orally active NaV1.7 inhibitor, with IC50s of 22.8 and 59.4 nM for hNaV1.7 and mNaV1.7, respectively. DS-1971a exerts analgesic effects.

Product information

CAS Number: 1450595-86-4

Molecular Weight: 465.93

Formula: C20H21ClFN5O3S

Chemical Name: 5-chloro-2-fluoro-4-{[(1S,2R)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl]oxy}-N-(pyrimidin-4-yl)benzene-1-sulfonamide

Smiles: CN1N=CC=C1[C@H]1CCCC[C@@H]1OC1=CC(F)=C(C=C1Cl)S(=O)(=O)NC1=CC=NC=N1

InChiKey: OJKONCJPCULNOW-DYVFJYSZSA-N

InChi: InChI=1S/C20H21ClFN5O3S/c1-27-16(6-9-25-27)13-4-2-3-5-17(13)30-18-11-15(22)19(10-14(18)21)31(28,29)26-20-7-8-23-12-24-20/h6-13,17H,2-5H2,1H3,(H,23,24,26)/t13-,17+/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

DS-1971a exhibits a favorable toxicological profile. DS-1971a (0.1-1 mg/kg; p.o.) shows mitigated thermal hyperalgesia in a dose-dependent manner in partial sciatic nerve ligation (PSL) mice.

Products are for research use only. Not for human use.

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