Description
Cinchophen is a potent and orally active non-steroidal anti-inflammatory agent, has analgesic and antimicrobial effects. Cinchophen can be used for the research of arthritis and some liver diseases.
Product information
CAS Number: 132-60-5
Molecular Weight: 249.26
Formula: C16H11NO2
Chemical Name: 2-phenylquinoline-4-carboxylic acid
Smiles: OC(=O)C1=CC(=NC2=CC=CC=C21)C1C=CC=CC=1
InChiKey: YTRMTPPVNRALON-UHFFFAOYSA-N
InChi: InChI=1S/C16H11NO2/c18-16(19)13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H,(H,18,19)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 83.33 mg/mL (334.31 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
Cinchophen (oral gavage; 25-44 mg/kg; twice daily) combines prednisolone ( 0.125-0.220 mg/kg; twice daily) for 14 days is effective in dogs with osteoarthritis and well tolerated. The combination exhibits significantly improved lameness, weight bearing, joint mobility and stiffness scores and is similar in clinical efficacy to phenylbutazone. The kinetics and efficacy of a cinchophen prednisolone combination preparation (PLT) is tested. Cinchophen administation at a dose rate of 12.5 mg/kg intravenously exhibits a volume of distribution (Vd area) of 0.13 L/kg, shows a clearance rate (Cl) of 0.15 L/h and a half-life (t1/2β) of 7.92 hours. The plasma concentration time curve (AUC0-∞) is 1187.0 μ/ml.h in dogs. Cinchophen administation (oral gavage; 12.5 mg/kg; single dose) exhibits a mean maximum plasma concentration (Cmax) of 77.75 μg/ml and the time of Cmax (tmax) is 2.76 hours. The plasma concentration time curve (AUC0-∞) is almost as large following oral as intravenous administration indicating an oral bioavailability (F) of 87.21%.
Products are for research use only. Not for human use.
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