6-Aminochrysene


Catalog No. Size PriceQuantity
M27865-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

6-Aminochrysene (6-Aminochrysene) is an aromatic amine used as a chemotherapeutic agent in the treatment of splenomegaly, myeloid leukemia, and breast cancer.

Product information

CAS Number: 2642-98-0

Molecular Weight: 243.30

Formula: C18H13N

Chemical Name: chrysen-6-amine

Smiles: NC1=CC2C(=CC=C3C=CC=CC3=2)C2=CC=CC=C21

InChiKey: KIVUHCNVDWYUNP-UHFFFAOYSA-N

InChi: InChI=1S/C18H13N/c19-18-11-17-13-6-2-1-5-12(13)9-10-15(17)14-7-3-4-8-16(14)18/h1-11H,19H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 6.67 mg/mL (27.41 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

6-Aminochrysene inhibits the hydroxylation of aniline, 0-demethylation of p-nitroanisole, and N-demethylation of aminopyrine by rat liver microsomes. Pre-treatment of rats with 6-aminochrysene markedly decreases the N-demethylation in vitro but significantly increases the hydroxylation and the 0-demethylation.

In Vivo:

6-Aminochrysene is an inhibitor of the growth of several solid experimental tumours in vivo and has a cancerostatic effect on human breast cancer. Long term topical skin application of 6-Aminochrysene to mice induces development of benign skin tumors after 3 months and of skin malignancies after 7 months. Female mice respond earlier than males. Induction of skin tumors is more rapid when 6-Aminochrysene is applied ventrally instead of dorsally. Urinary excretion is about twice as high after skin application than after oral administration.

Products are for research use only. Not for human use.

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