Description
AKT-IN-3 (compound E22) is a potent, orally active low hERG blocking Akt inhibitor, with 1.4 nM, 1.2 nM and 1.7 nM for Akt1, Akt2 and Akt3, respectively. AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kinases, such as PKA, PKC, ROCK1, RSK1, P70S6K, and SGK. AKT-IN-3 (compound E22) induces apoptosis and inhibits metastasis of cancer cells.
Product information
CAS Number: 2374740-21-1
Molecular Weight: 526.36
Formula: C23H23Cl2F2N5O3
Chemical Name: 5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-N-[(3S,4S,6S)-4-(3,4-difluorophenyl)-6-[(methylcarbamoyl)methyl]piperidin-3-yl]furan-2-carboxamide
Smiles: CNC(=O)C[C@@H]1C[C@H]([C@@H](CN1)NC(=O)C1=CC(=C(Cl)O1)C1=C(Cl)C=NN1C)C1C=C(F)C(F)=CC=1
InChiKey: SXDPQGRNHSLZPC-ZJNRKIDTSA-N
InChi: InChI=1S/C23H23Cl2F2N5O3/c1-28-20(33)7-12-6-13(11-3-4-16(26)17(27)5-11)18(10-29-12)31-23(34)19-8-14(22(25)35-19)21-15(24)9-30-32(21)2/h3-5,8-9,12-13,18,29H,6-7,10H2,1-2H3,(H,28,33)(H,31,34)/t12-,13-,18+/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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