Description
HBDDE, a derivative of Ellagic acid, is an isoform-selective PKCα and PKCγ inhibitor with IC50s of 43 μM and 50 μM, respectively. HBDDE shows selective for PKCα/PKCγ over PKCδ, PKCβI and PKCβII isozymes. HBDDE induces neuronal apoptosis.
Product information
CAS Number: 154675-18-0
Molecular Weight: 338.31
Formula: C16H18O8
Chemical Name: 6,6'-bis(methoxymethyl)-[1,1'-biphenyl]-2,2',3,3',4,4'-hexol
Smiles: COCC1=CC(O)=C(O)C(O)=C1C1=C(COC)C=C(O)C(O)=C1O
InChiKey: NEBCAMAQXZIVRE-UHFFFAOYSA-N
InChi: InChI=1S/C16H18O8/c1-23-5-7-3-9(17)13(19)15(21)11(7)12-8(6-24-2)4-10(18)14(20)16(12)22/h3-4,17-22H,5-6H2,1-2H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
HBDDE (50 μM; 5 hours) treatment reduces cell viability significantly by ~70%. HBDDE exhibits a marked increase in caspase-3 activity.
Products are for research use only. Not for human use.
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