Description
IQ-R is a novel hypoxia-sensitive fluorescent probe, consisting of an indolequinone unit and a rhodol fluorophore.Target:IQ-R has good solubility in water and longer wavelength for absorption and emission, which are favorable for cellular bioimaging. While the fluorescence of rhodol in the IQ-R conjugate is quenched by the function of intramolecular indolequinone unit, it is restored under hypoxic conditions through the enzymatic one-electron reduction of IQ-R by NADPH: cytochrome P450 reductase to release the nonconjugated free rhodol. When administered to A549 cells, IQ-R is activated and reduced by endogenous reductase preferentially under hypoxic conditions, thereby visualizing hypoxic cancer cells by robust fluorescence.
Product information
CAS Number: 1345445-57-9
Molecular Weight: 576.60
Formula: C34H28N2O7
Chemical Name: (5-methoxy-1,2-dimethyl-4,7-dioxo-4,7-dihydro-1H-indol-3-yl)methyl 2-[6-(dimethylamino)-3-oxo-3H-xanthen-9-yl]benzoate
Smiles: CN(C)C1=CC2OC3=CC(=O)C=CC3=C(C3=CC=CC=C3C(=O)OCC3C4=C(C(=O)C=C(OC)C4=O)N(C)C=3C)C=2C=C1
InChiKey: XAVOZQBGUYUYJD-UHFFFAOYSA-N
InChi: InChI=1S/C34H28N2O7/c1-18-25(31-32(36(18)4)26(38)16-29(41-5)33(31)39)17-42-34(40)22-9-7-6-8-21(22)30-23-12-10-19(35(2)3)14-27(23)43-28-15-20(37)11-13-24(28)30/h6-16H,17H2,1-5H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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