Description
S-Gboxin, a functional analogue of Gboxin, inhibits growth of mouse and human glioblastoma (GBM) with an IC50 of 470 nM. Antitumour activity.
Product information
CAS Number: 2101317-21-7
Molecular Weight: 600.45
Formula: C27H32F3IN2O2
Chemical Name: 3-methyl-1-(2-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2-oxoethyl)-2-[3-(trifluoromethyl)phenyl]-1H-1,3-benzodiazol-3-ium iodide
Smiles: [I-].CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)CN1C(C2=CC(=CC=C2)C(F)(F)F)=[N+](C)C2=CC=CC=C12
InChiKey: DCAJNAWCJSUZDG-DZJKTSMVSA-M
InChi: InChI=1S/C27H32F3N2O2.HI/c1-17(2)21-13-12-18(3)14-24(21)34-25(33)16-32-23-11-6-5-10-22(23)31(4)26(32)19-8-7-9-20(15-19)27(28,29)30;/h5-11,15,17-18,21,24H,12-14,16H2,1-4H3;1H/q+1;/p-1/t18-,21+,24-;/m1./s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 93.33 mg/mL (155.43 mM; Need ultrasonic). H2O : 1 mg/mL (1.67 mM; ultrasonic and warming and heat to 67°C).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
S-Gboxin retains excellent metabolic stability, enhanced plasma stability, and PK-properties suitable for in vivo studies. S-Gboxin (10 mg/kg/day; intraperitoneally) inhibits glioblastoma (GBM) growth in vivo.
Products are for research use only. Not for human use.
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