IK1 inhibitor PA-6


Catalog No. Size PriceQuantity
M28576-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

IK1 inhibitor PA-6 (PA-6), a pentamidine analogue, is a selective and potent IK1 (KIR2.x ion-channel-carried inward rectifier current) inhibitor, with IC50 values of 12-15 nM for human and mouse KIR2.x currents. IK1 inhibitor PA-6 (PA-6) elevates KIR2.1 protein expression and induces intracellular KIR2.1 accumulation. IK1 inhibitor PA-6 (PA-6) has the potential to treat atrial fibrillation and arrhythmia.

Product information

CAS Number: 500715-03-7

Molecular Weight: 492.61

Formula: C31H32N4O2

Chemical Name: N'-(4-{[5-(4-{[amino(phenyl)methylidene]amino}phenoxy)pentyl]oxy}phenyl)benzenecarboximidamide

Smiles: NC(=NC1C=CC(=CC=1)OCCCCCOC1C=CC(=CC=1)N=C(N)C1C=CC=CC=1)C1C=CC=CC=1

InChiKey: PETGITKEGWIZEL-UHFFFAOYSA-N

InChi: InChI=1S/C31H32N4O2/c32-30(24-10-4-1-5-11-24)34-26-14-18-28(19-15-26)36-22-8-3-9-23-37-29-20-16-27(17-21-29)35-31(33)25-12-6-2-7-13-25/h1-2,4-7,10-21H,3,8-9,22-23H2,(H2,32,34)(H2,33,35)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 125 mg/mL (253.75 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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