SHP2-IN-6


Catalog No. Size PriceQuantity
M28728-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

SHP2-IN-6 is a potent SHP2 inhibitor, extracted from patent WO2017211303A1, compound 7, has an IC50 of 25.8 nM.

Product information

CAS Number: 2169223-48-5

Molecular Weight: 476.54

Formula: C22H26F2N6O2S

Chemical Name: 1-[4-({3-amino-5-[(4S)-4-amino-2-oxa-8-azaspiro[4.5]decan-8-yl]pyrazin-2-yl}sulfanyl)-3,3-difluoro-2,3-dihydro-1H-indol-1-yl]ethan-1-one

Smiles: CC(=O)N1CC(F)(F)C2=C(C=CC=C12)SC1=NC=C(N=C1N)N1CCC2(COC[C@H]2N)CC1

InChiKey: HGYTYZKWKUXRKA-MRXNPFEDSA-N

InChi: InChI=1S/C22H26F2N6O2S/c1-13(31)30-11-22(23,24)18-14(30)3-2-4-15(18)33-20-19(26)28-17(9-27-20)29-7-5-21(6-8-29)12-32-10-16(21)25/h2-4,9,16H,5-8,10-12,25H2,1H3,(H2,26,28)/t16-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

SHP2-IN-6 inhibits the proliferation of KYSE-520 cells with an IC50 of 2.17 μM.

Products are for research use only. Not for human use.

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