JAK/HDAC-IN-1


Catalog No. Size PriceQuantity
M28734-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

JAK/HDAC-IN-1 is a potent JAK2/HDAC dual inhibitor, exhibits antiproliferative and proapoptotic activities in several hematological cell lines. JAK/HDAC-IN-1 shows IC50s of 4 and 2 nM for JAK2 and HDAC, respectively.

Product information

CAS Number: 2284621-75-4

Molecular Weight: 450.32

Formula: C19H21Cl2N7O2

Chemical Name: 6-[4-({5-chloro-4-[(4-chlorophenyl)amino]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]-N-hydroxyhexanamide

Smiles: ONC(=O)CCCCCN1C=C(C=N1)NC1=NC(NC2C=CC(Cl)=CC=2)=C(Cl)C=N1

InChiKey: MTOQNLGMTJOJOF-UHFFFAOYSA-N

InChi: InChI=1S/C19H21Cl2N7O2/c20-13-5-7-14(8-6-13)24-18-16(21)11-22-19(26-18)25-15-10-23-28(12-15)9-3-1-2-4-17(29)27-30/h5-8,10-12,30H,1-4,9H2,(H,27,29)(H2,22,24,25,26)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 20.83 mg/mL (46.26 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

JAK/HDAC-IN-1 (Compound 8m) exhibits IC50s of 4.8, 7.4 and 49 nM for JAK1, JAK3 and TYK2, and 14, 120, 2470 nM for HDAC2, HDAC6 and HDAC8, respectively.

Products are for research use only. Not for human use.

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