CHDI-390576


Catalog No. Size PriceQuantity
M28745-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

CHDI-390576, a potent, cell permeable and CNS penetrant class IIa histone deacetylase (HDAC) inhibitor with IC50s of 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9, respectively, shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform.

Product information

CAS Number: 1629729-98-1

Molecular Weight: 391.32

Formula: C19H13F4N3O2

Chemical Name: 2-(2-fluorophenyl)-N-hydroxy-2-{4-[5-(trifluoromethyl)pyrimidin-2-yl]phenyl}acetamide

Smiles: ONC(=O)C(C1=CC=CC=C1F)C1C=CC(=CC=1)C1N=CC(=CN=1)C(F)(F)F

InChiKey: LMGDHGQJJLEAPQ-UHFFFAOYSA-N

InChi: InChI=1S/C19H13F4N3O2/c20-15-4-2-1-3-14(15)16(18(27)26-28)11-5-7-12(8-6-11)17-24-9-13(10-25-17)19(21,22)23/h1-10,16,28H,(H,26,27)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 250 mg/mL (638.86 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

The affinity (Kd) of CHDI-390576 to the catalytic domain of immobilized HDAC4 is 80 nM. CHDI-390576 inhibits class I HDACs (1, 3, 8) and class IIb HDAC6 isoforms with IC50s of 39.7μM, 25.8 μM, 9.1 μM, 6.2 μM, respectively.

Products are for research use only. Not for human use.

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