Description
SMS1-IN-1, compound SAPA 1j, is a novel and the most potent sphingomyelin synthase 1 (SMS1) inhibitor with an IC50 value of 2.1 μM. SMS1-IN-1 has the potential for the treatment of atherosclerosis.
Product information
CAS Number: 1807943-38-9
Molecular Weight: 503.41
Formula: C23H23BrN2O4S
Chemical Name: N-[(4-bromophenyl)methyl]-2-{4-[(2-phenylethyl)sulfamoyl]phenoxy}acetamide
Smiles: O=C(COC1C=CC(=CC=1)S(=O)(=O)NCCC1C=CC=CC=1)NCC1C=CC(Br)=CC=1
InChiKey: CZAFIFBJBFDMTP-UHFFFAOYSA-N
InChi: InChI=1S/C23H23BrN2O4S/c24-20-8-6-19(7-9-20)16-25-23(27)17-30-21-10-12-22(13-11-21)31(28,29)26-15-14-18-4-2-1-3-5-18/h1-13,26H,14-17H2,(H,25,27)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
SMS1-IN-1 (2.5, 10 and 50 μM) has a dose-dependent inhibitory effect against SMS1, and is against SMS1 with an IC50 value of 2.1 μM.
Products are for research use only. Not for human use.
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