SHIP2-IN-1


Catalog No. Size PriceQuantity
M29017-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

SHIP2-IN-1 is a potent SHIP2 inhibitor, inhibits SHIP2 activity, with an IC50 of 2 µM. SHIP2-IN-1 blocks GSK3β activation by phosphorylation at the Ser9 residue. SHIP2-IN-1 is used in the research of Alzheimer’s disease.

Product information

CAS Number: 2252247-80-4

Molecular Weight: 379.22

Formula: C17H13Cl2FN4O

Chemical Name: 5-{5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl}pyrimidin-2-amine

Smiles: C[C@@H](OC1=CN=CC(=C1)C1=CN=C(N)N=C1)C1=C(Cl)C(F)=CC=C1Cl

InChiKey: ATPYDXUUBCDYKQ-SECBINFHSA-N

InChi: InChI=1S/C17H13Cl2FN4O/c1-9(15-13(18)2-3-14(20)16(15)19)25-12-4-10(5-22-8-12)11-6-23-17(21)24-7-11/h2-9H,1H3,(H2,21,23,24)/t9-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (263.70 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

SHIP2-IN-1 (Compound 43; 10 µM) significantly inhibits PI(3,4)P2 production in HT22 cells.

Products are for research use only. Not for human use.

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