Description
endo-BCN-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
Product information
CAS Number: 1807501-86-5
Molecular Weight: 538.59
Formula: C26H38N2O10
Chemical Name: 2,5-dioxopyrrolidin-1-yl 1-{[({bicyclo[6.1.0]non-4-yn-9-yl}methoxy)carbonyl]amino}-3,6,9,12-tetraoxapentadecan-15-oate
Smiles: O=C(NCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O)OCC1C2CCC#CCCC21
InChiKey: MFQCOKMBYCIQEJ-UHFFFAOYSA-N
InChi: InChI=1S/C26H38N2O10/c29-23-7-8-24(30)28(23)38-25(31)9-11-33-13-15-35-17-18-36-16-14-34-12-10-27-26(32)37-19-22-20-5-3-1-2-4-6-21(20)22/h20-22H,3-19H2,(H,27,32)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Products are for research use only. Not for human use.
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