GSK717


Catalog No. Size PriceQuantity
M29519-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor. GSK717 inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, with an IC50 of 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells.

Product information

CAS Number: 1595278-21-9

Molecular Weight: 452.55

Formula: C28H28N4O2

Chemical Name: N-[2-(1-{[(2,3-dihydro-1H-inden-5-yl)carbamoyl]methyl}-1H-1,3-benzodiazol-2-yl)ethyl]-N-methylbenzamide

Smiles: CN(CCC1=NC2=CC=CC=C2N1CC(=O)NC1=CC2CCCC=2C=C1)C(=O)C1C=CC=CC=1

InChiKey: YDOATJUIIFWTKQ-UHFFFAOYSA-N

InChi: InChI=1S/C28H28N4O2/c1-31(28(34)21-8-3-2-4-9-21)17-16-26-30-24-12-5-6-13-25(24)32(26)19-27(33)29-23-15-14-20-10-7-11-22(20)18-23/h2-6,8-9,12-15,18H,7,10-11,16-17,19H2,1H3,(H,29,33)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 250 mg/mL (552.43 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

GSK717 blocks synergy between NOD2 and TLR2. GSK717 does not affect NOD1, TNFR1 and TLR2-mediated responses. GSK717 (5 μM) inhibits the release of IL-8, IL-6, TNFα and IL-1β in primary human monocytes stimulated with MDP.

Products are for research use only. Not for human use.

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