PHT-7.3


Catalog No. Size PriceQuantity
M30042-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

PHT-7.3 is a selective inhibitor of connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain (Kd=4.7 μM). PHT-7.3 inhibits mut-KRas, but not wild-type KRas cancer cell and tumor growth and signaling. PHT-7.3 has antitumor activity.

Product information

CAS Number: 1614225-93-2

Molecular Weight: 433.52

Formula: C24H23N3O3S

Chemical Name: 4-[(1,3-dioxan-2-yl)methyl]-2-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}-1,2-dihydrophthalazin-1-one

Smiles: CC1C=CC(=CC=1)C1=CSC(CN2N=C(CC3OCCCO3)C3=CC=CC=C3C2=O)=N1

InChiKey: AFPMVLVIYVAFSP-UHFFFAOYSA-N

InChi: InChI=1S/C24H23N3O3S/c1-16-7-9-17(10-8-16)21-15-31-22(25-21)14-27-24(28)19-6-3-2-5-18(19)20(26-27)13-23-29-11-4-12-30-23/h2-3,5-10,15,23H,4,11-14H2,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 62.5 mg/mL (144.17 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

PHT-7.3 (200 mg/kg; i.p.; daily; for 20 days) exhibits cytostatic antitumor activity in the mut-KRas(G12S) A549 xenograft and mut-KRasG12V H441 xenograft.

Products are for research use only. Not for human use.

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