AZD4694


Catalog No. Size PriceQuantity
M30101-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

AZD4694, a fluorinated β-amyloid (Aβ) plaque neuroimaging PET radioligand, shows high affinity for Aβ fibrils (Kd = 2.3 nM).

Product information

CAS Number: 1054629-49-0

Molecular Weight: 258.25

Formula: C14H11FN2O2

Chemical Name: 2-[2-fluoro-6-(methylamino)pyridin-3-yl]-1-benzofuran-5-ol

Smiles: CNC1=CC=C(C(F)=N1)C1=CC2=CC(O)=CC=C2O1

InChiKey: MYNQXTDIPMCJCR-UHFFFAOYSA-N

InChi: InChI=1S/C14H11FN2O2/c1-16-13-5-3-10(14(15)17-13)12-7-8-6-9(18)2-4-11(8)19-12/h2-7,18H,1H3,(H,16,17)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

Administration of unlabeled AZD4694 to rat showed that it has a pharmacokinetic profile consistent with good PET radioligands, it quickly entered and rapidly cleared from normal rat brain tissue. AZD4694 (4 mL/kg; intravenous injection) inhibits [3H]AZD2184 binding (1 nM) in a concentration-dependent manner, with a Ki of 23.1 nM, in postmortem brain sections from AD patients.

Products are for research use only. Not for human use.

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