Description
Amoscanate (cgp4540) is phenyl isothiocyanate in which the hydrogen at the para-position has been replaced by a 4-nitroanilinyl group. Amoscanate is an anti-schistosomal agent. Amoscanate, as an isothiocyanate compound and uncoupler of oxidative phosphorylation, potently injures rodent ependyma.
Product information
CAS Number: 100990-46-3
Molecular Weight: 271.29
Formula: C13H9N3O2S
Chemical Name: N-(4-isothiocyanatophenyl)-4-nitroaniline
Smiles: [O-][N+](=O)C1C=CC(=CC=1)NC1C=CC(=CC=1)N=C=S
InChiKey: DKVNAGXPRSYHLB-UHFFFAOYSA-N
InChi: InChI=1S/C13H9N3O2S/c17-16(18)13-7-5-12(6-8-13)15-11-3-1-10(2-4-11)14-9-19/h1-8,15H
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
Amoscanate (500 mg/kg; p.o.; 10 days) destructs ependyma and periventricular brain. Amoscanate (250 and 500 mg/kg; p.o.; 28 days) elicits necrosis, Ca++-positive microgranules, pyknosis and edema localized in ependyma/subependyma in the medial striatum. Amoscanate (25~500 mg/kg; p.o.; 20 days) elicits progressive necrosis of ependyma. Amoscanate elicits massive ultrastructural damage in ependymal cells.
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