Description
ACH-000143 is a potent and orally active melatonin receptor agonist, with EC50 values of 0.06 nM and 0.32 nM for MT1 and MT2, respectively.
Product information
CAS Number: 2225836-30-4
Molecular Weight: 297.74
Formula: C13H16ClN3O3
Chemical Name: N-[2-(5-chloro-2,6-dimethoxy-1H-1,3-benzodiazol-1-yl)ethyl]acetamide
Smiles: CC(=O)NCCN1C(=NC2=CC(Cl)=C(C=C12)OC)OC
InChiKey: BVSLRGAPRGQWNC-UHFFFAOYSA-N
InChi: InChI=1S/C13H16ClN3O3/c1-8(18)15-4-5-17-11-7-12(19-2)9(14)6-10(11)16-13(17)20-3/h6-7H,4-5H2,1-3H3,(H,15,18)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 50 mg/mL (167.93 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
ACH-000143 reduces liver triglycerides and steatosis in diet-Induced obese rats. ACH-000143 is devoid of hERG binding, genotoxicity, and behavioral alterations at doses up to 100 mg/kg p.o., supporting further investigation of this compound as a drug candidate. ACH-000143 significantly reduces plasma glucose at 10 mg/kg (−16.4%, p < 0.05) and 30 mg/kg (−16.9%, p < 0.01).
Products are for research use only. Not for human use.
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