Description
IACS-8803 is a highly potent cyclic dinucleotide STING agonist with robust systemic antitumor efficacy.
Product information
CAS Number: 2095690-70-1
Molecular Weight: 692.53
Formula: C20H23FN10O9P2S2
Chemical Name: (1R,6R,8R,9R,10R,15R,17R,18R)-8,17-bis(6-amino-9H-purin-9-yl)-9-fluoro-3,18-dihydroxy-12-sulfanyl-3-sulfanylidene-2,4,7,11,13,16-hexaoxa-3λ⁵,12λ⁵-diphosphatricyclo[13.2.1.0⁶,¹⁰]octadecan-12-one
Smiles: NC1=NC=NC2=C1N=CN2[C@@H]1O[C@@H]2COP(=O)(S)O[C@H]3[C@@H](F)[C@@H](O[C@@H]3COP(O)(=S)O[C@@H]1[C@@H]2O)N1C=NC2=C1N=CN=C2N
InChiKey: CMVAAKLGZJHFOY-ABTIDCMQSA-N
InChi: InChI=1S/C20H23FN10O9P2S2/c21-9-13-8(38-19(9)30-5-28-10-15(22)24-3-26-17(10)30)2-36-42(34,44)40-14-12(32)7(1-35-41(33,43)39-13)37-20(14)31-6-29-11-16(23)25-4-27-18(11)31/h3-9,12-14,19-20,32H,1-2H2,(H,33,43)(H,34,44)(H2,22,24,26)(H2,23,25,27)/t7-,8-,9-,12-,13-,14-,19-,20-,41?,42?/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: H2O : 15 mg/mL (21.66 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
IACS-8803 shows a superior systemic anti-tumor response in the B16 murine model of melanoma.
Products are for research use only. Not for human use.
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