ICAM-1-IN-1


Catalog No. Size PriceQuantity
M30231-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

ICAM-1-IN-1 is a potent and selective inhibitor of E-selectin and ICAM-1 with IC50 values of 7 and 5 nM, respectively.

Product information

CAS Number: 251994-14-6

Molecular Weight: 363.23

Formula: C15H11BrN2O2S

Chemical Name: 4-(4-bromophenoxy)-N-methylthieno[2,3-c]pyridine-2-carboxamide

Smiles: CNC(=O)C1=CC2C(=CN=CC=2OC2C=CC(Br)=CC=2)S1

InChiKey: OFXAEWYLVPBGGU-UHFFFAOYSA-N

InChi: InChI=1S/C15H11BrN2O2S/c1-17-15(19)13-6-11-12(7-18-8-14(11)21-13)20-10-4-2-9(16)3-5-10/h2-8H,1H3,(H,17,19)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 135 mg/mL (371.67 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

ICAM-1-IN-1 shows significant efficacy in a rat rheumatoid arthritis model and in a mouse asthma model. ICAM-1-IN-1 reduces the width of inflamed ankles after the ninth day following treatment, but shows no efficacy in the acute phase. Treatment with ICAM-1-IN-1 (25 mg/kg) for 21 days significantly reduces the ankle inflammation of the arthritis rats. Significant reduction of eosinophils and serum-soluble ICAM-1 (sICAM-1) is observed.

Products are for research use only. Not for human use.

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