Description
RGH-5526 (GYKI-11679) is a new antihypertensive agent.
Product information
CAS Number: 69579-13-1
Molecular Weight: 335.40
Formula: C16H25N5O3
Chemical Name: tert-butyl (3E)-3-{2-[6-(morpholin-4-yl)pyridazin-3-yl]hydrazin-1-ylidene}butanoate
Smiles: C/C(/CC(=O)OC(C)(C)C)=N\NC1=CC=C(N=N1)N1CCOCC1
InChiKey: YCVVCSICMNKDBE-SFQUDFHCSA-N
InChi: InChI=1S/C16H25N5O3/c1-12(11-15(22)24-16(2,3)4)17-18-13-5-6-14(20-19-13)21-7-9-23-10-8-21/h5-6H,7-11H2,1-4H3,(H,18,19)/b17-12+
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
RGH-5526 (GYKI-11679) is a new antihypertensive agent. Results show a sharp (61%) reduction in the hypothalamic Noradrenaline (NA) level 2 h after the administration of 10 mg/kg of RGH-5526, and this effect lasts for 4 to 6 h. It is demonstrated that RGH-5526 exerts a greater NA lowering effect in the hypothalamus than in the periphery. RGH-5526 does not influence the hypothalamic monoamine oxidase (MAO)-activity following prolonged treatment.
Products are for research use only. Not for human use.
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