c-met-IN-1


Catalog No. Size PriceQuantity
M30734-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

c-met-IN-1 (compound 16) is a potent and selective c-Met inhibitor, with IC50 of 1.1 nM, with antitumor activity..

Product information

CAS Number: 2084836-84-8

Molecular Weight: 640.70

Formula: C35H37FN6O5

Chemical Name: N-[3-fluoro-4-({6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinolin-4-yl}oxy)phenyl]-1-(2-methoxyphenyl)-1H-imidazole-4-carboxamide

Smiles: CN1CCN(CCCOC2=CC3=NC=CC(OC4=CC=C(C=C4F)NC(=O)C4=CN(C=N4)C4=CC=CC=C4OC)=C3C=C2OC)CC1

InChiKey: SJSWLZFLXRBNSJ-UHFFFAOYSA-N

InChi: InChI=1S/C35H37FN6O5/c1-40-14-16-41(17-15-40)13-6-18-46-34-21-27-25(20-33(34)45-3)30(11-12-37-27)47-31-10-9-24(19-26(31)36)39-35(43)28-22-42(23-38-28)29-7-4-5-8-32(29)44-2/h4-5,7-12,19-23H,6,13-18H2,1-3H3,(H,39,43)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

c-met-IN-1 (compound 16) exhibits high selectivity and remarkable cytotoxicity against HT-29, MKN-45 and A549 cells with IC50 values of 0.08 μM, 0.22 μM and 0.07 μM, respectively.

Products are for research use only. Not for human use.

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