ALK-IN-5


Catalog No. Size PriceQuantity
M30821-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK), with an IC50 of 2.9 nM.

Product information

CAS Number: 2351929-66-1

Molecular Weight: 464.49

Formula: C24H25FN6O3

Chemical Name: (2S)-4-{6-[(1S)-1-(5-fluoropyridin-2-yl)ethoxy]-1-(5-methyl-1H-pyrazol-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl}-2-methylmorpholine

Smiles: CC1=CC(=NN1)N1C=C(C(=O)N2C[C@H](C)OCC2)C2=CC=C(N=C12)O[C@@H](C)C1=CC=C(F)C=N1

InChiKey: UTDAGOYVDYQGFI-HOTGVXAUSA-N

InChi: InChI=1S/C24H25FN6O3/c1-14-10-21(29-28-14)31-13-19(24(32)30-8-9-33-15(2)12-30)18-5-7-22(27-23(18)31)34-16(3)20-6-4-17(25)11-26-20/h4-7,10-11,13,15-16H,8-9,12H2,1-3H3,(H,28,29)/t15-,16-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

ALK-IN-5 potently inhibits ALK with cellular IC50 of 27 nM.

Products are for research use only. Not for human use.

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