M2N12


Catalog No. Size PriceQuantity
M30827-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

M2N12 is a potent and highly selective cell division cycle 25C protein phosphatase (Cdc25C) inhibitor with an IC50 value of 0.09  μM. M2N12 also has promising activity against Cdc25A and Cdc25B with IC50 values of  0.53  μM and 1.39 μM, respectively. M2N12 has anti-tumor activity and can be used for cancer research.

Product information

CAS Number: 2376577-06-7

Molecular Weight: 393.83

Formula: C20H16ClN5O2

Chemical Name: 6-chloro-7-[({1-[(4-methylphenyl)methyl]-1H-1,2,3-triazol-4-yl}methyl)amino]-5,8-dihydroquinoline-5,8-dione

Smiles: CC1C=CC(CN2C=C(CNC3=C(Cl)C(=O)C4=CC=CN=C4C3=O)N=N2)=CC=1

InChiKey: BDBIMDYALUJAPR-UHFFFAOYSA-N

InChi: InChI=1S/C20H16ClN5O2/c1-12-4-6-13(7-5-12)10-26-11-14(24-25-26)9-23-18-16(21)19(27)15-3-2-8-22-17(15)20(18)28/h2-8,11,23H,9-10H2,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

M2N12 (0-20 μM; 72 hours) has cytotoxic activity against five tumor cell lines and a normal cell line including A-549, MDA-MB-231, KB, KB-VIN, MCF-7 and HBE (IC50=3.92 μM, 4.63 μM, 5.05 μM, 6.81 μM, 4.71 μM and 6.00 μM, respectively).

Products are for research use only. Not for human use.

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