Description
CDK9-IN-9 (example 2) is a potent and selective CDK9 inhibitor with an IC50 of 1.8 nM. CDK9-IN-9 inhibits CDK2 with an IC50 of 155 nM. CDK9-IN-9 has anti-cancer activity.
Product information
CAS Number: 2246956-84-1
Molecular Weight: 459.51
Formula: C22H23F2N5O2S
Chemical Name: ({3,20-difluoro-13-oxa-5,7,18,25-tetraazatetracyclo[17.3.1.1²,⁶.1⁸,¹²]pentacosa-1(23),2,4,6(25),8,10,12(24),19,21-nonaen-10-yl}methyl)(imino)methyl-λ⁶-sulfanone
Smiles: CS(=N)(=O)CC1C=C2C=C(C=1)OCCCCNC1C=C(C=CC=1F)C1N=C(N2)N=CC=1F
InChiKey: PNHBMABVSBQFDU-UHFFFAOYSA-N
InChi: InChI=1S/C22H23F2N5O2S/c1-32(25,30)13-14-8-16-11-17(9-14)31-7-3-2-6-26-20-10-15(4-5-18(20)23)21-19(24)12-27-22(28-16)29-21/h4-5,8-12,25-26H,2-3,6-7,13H2,1H3,(H,27,28,29)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
CDK9-IN-9 (example 2) inhibits the proliferation of HeLa, HeLa-MaTu-ADR, NCI-H460, DU145, Caco-2, B16F10, A2780 and MOLM-13 cells with IC50s of 4.4 nM, 5.3 nM, 9.2 nM, 4.5 nM, 8.4 nM, 1.2 nM, 1.2 nM, 2.0 nM, respectively.
Products are for research use only. Not for human use.
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