Dynarrestin


Catalog No. Size PriceQuantity
M31188-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Dynarrestin is a aminothiazole inhibitor of cytoplasmic dyneins 1 and 2. Dynarrestin rapidly and reversibly inhibits dynein 1-driven microtubule gliding in vitro plus a range of dynein 1- and 2-dependent processes in cells without affecting ATP hydrolysis and interfering with ciliogenesis. Dynarrestin suppresses hedgehog (Hh)-dependent proliferation of neuronal precursors and tumor cells.

Product information

CAS Number: 2222768-84-3

Molecular Weight: 431.50

Formula: C22H23F2N3O2S

Chemical Name: ethyl 4-[4-(diethylamino)phenyl]-2-[(2,4-difluorophenyl)amino]-1,3-thiazole-5-carboxylate

Smiles: CCOC(=O)C1SC(NC2=CC=C(F)C=C2F)=NC=1C1C=CC(=CC=1)N(CC)CC

InChiKey: UZNNDDDSGCMQOQ-UHFFFAOYSA-N

InChi: InChI=1S/C22H23F2N3O2S/c1-4-27(5-2)16-10-7-14(8-11-16)19-20(21(28)29-6-3)30-22(26-19)25-18-12-9-15(23)13-17(18)24/h7-13H,4-6H2,1-3H3,(H,25,26)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 83.33 mg/mL (193.12 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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