DDR1-IN-6


Catalog No. Size PriceQuantity
M31650-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

DDR1-IN-6 is a selective Discoidin Domain Receptor family, member 1 (DDR1) inhibitor with an IC50 of 9.72 nM. DDR1-IN-6 inhibits auto-phosphorylation DDR1b (Y513) with an IC50 of 9.7 nM. DDR1-IN-6 has anti-cancer activity.

Product information

CAS Number: 2416021-47-9

Molecular Weight: 433.39

Formula: C23H14F3N5O

Chemical Name: 7-(2-{imidazo[1,2-b]pyridazin-3-yl}ethynyl)-6-methyl-N-[3-(trifluoromethyl)phenyl]-1,2-benzoxazol-3-amine

Smiles: CC1=CC=C2C(NC3=CC(=CC=C3)C(F)(F)F)=NOC2=C1C#CC1=CN=C2C=CC=NN21

InChiKey: GDBAAUWGHRTFSE-UHFFFAOYSA-N

InChi: InChI=1S/C23H14F3N5O/c1-14-7-9-19-21(18(14)10-8-17-13-27-20-6-3-11-28-31(17)20)32-30-22(19)29-16-5-2-4-15(12-16)23(24,25)26/h2-7,9,11-13H,1H3,(H,29,30)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

DDR1-IN-6 (compound 1; for 24 hours) inhibits collagen production in human hepatic stellate cell LX-2 (IC50=13 nM). DDR1-IN-6 (72 hours) has cytotoxicity in LX-2 cells (CC50=3 μM). DDR1-IN-6 (0-30 μM) has anti-proliferation effects on primary tumor cells freshly isolated from PC-07-0024 (IC50=5.7 μM of 3 days; IC50=2.65 μM of 6 days) and LU-01-0523 derived xenograft (PDX) tumor model (IC50>30 μM of 3 days; IC50>30 μM of 6 days).

Products are for research use only. Not for human use.

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