BI-9321 trihydrochloride


Catalog No. Size PriceQuantity
M31861-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

BI-9321 trihydrochloride is a potent, selective and cellular active nuclear receptor-binding SET domain 3 (NSD3)-PWWP1 domain antagonist with a Kd value of 166 nM. BI-9321 trihydrochloride is inactive against NSD2-PWWP1 and NSD3-PWWP2. BI-9321 trihydrochloride specifically disrupts histone interactions of the NSD3-PWWP1 domain with an IC50 of 1.2 μM in U2OS cells.

Product information

CAS Number: 2387510-87-2

Molecular Weight: 469.81

Formula: C22H24Cl3FN4

Chemical Name: 1-{4-[5-(7-fluoroquinolin-4-yl)-1-methyl-1H-imidazol-4-yl]-3,5-dimethylphenyl}methanamine trihydrochloride

Smiles: Cl.Cl.Cl.CC1C=C(CN)C=C(C)C=1C1N=CN(C)C=1C1=CC=NC2=CC(F)=CC=C12

InChiKey: DCDXMBVQCRHZMW-UHFFFAOYSA-N

InChi: InChI=1S/C22H21FN4.3ClH/c1-13-8-15(11-24)9-14(2)20(13)21-22(27(3)12-26-21)18-6-7-25-19-10-16(23)4-5-17(18)19;;;/h4-10,12H,11,24H2,1-3H3;3*1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 250 mg/mL (532.13 mM; Need ultrasonic). H2O : 25 mg/mL (53.21 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

BI-9321 trihydrochloride is targeting the methyl-lysine binding site of the PWWP1 domain with sub-micromolar in vitro activity and cellular target engagement at 1 µM. As a single agent, BI-9321 trihydrochloride downregulates Myc messenger RNA expression and reduces proliferation in MOLM-13 cells.

Products are for research use only. Not for human use.

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