c-Fms-IN-6


Catalog No. Size PriceQuantity
M31868-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

c-Fms-IN-6 is a potent inhibitor of c-FMS, with an IC50 of ≤10 nM for unphosphorylated c-FMS, also weakly inhibits unphosphorylated c-KIT and PDGFR (IC50, > 1 μM). Used in the research of autoimmune diseases.

Product information

CAS Number: 1628574-81-1

Molecular Weight: 419.48

Formula: C22H25N7O2

Chemical Name: 3-tert-butyl-1-(5-{[2-(1-ethyl-1H-pyrazol-4-yl)pyridin-4-yl]oxy}-6-methylpyridin-2-yl)-4,5-dihydro-1H-1,2,4-triazol-5-one

Smiles: CC1=NC(=CC=C1OC1=CC(=NC=C1)C1C=NN(CC)C=1)N1N=C(NC1=O)C(C)(C)C

InChiKey: NWTRDIYLEGZNSX-UHFFFAOYSA-N

InChi: InChI=1S/C22H25N7O2/c1-6-28-13-15(12-24-28)17-11-16(9-10-23-17)31-18-7-8-19(25-14(18)2)29-21(30)26-20(27-29)22(3,4)5/h7-13H,6H2,1-5H3,(H,26,27,30)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

c-Fms-IN-6 (Example 38) shows inhibitory activity against M-NFS-60 cell proliferation, with an IC50 in the range of 0.01 μM to 0.1 μM.

Products are for research use only. Not for human use.

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