NSAH


Catalog No. Size PriceQuantity
M31906-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

NSAH is a reversible and competitive nonnucleoside ribonucleotide reductase (RR) inhibitor, with cell-free IC50 of 32 μM and cell-based IC50 of ~250 nM, respectively.

Product information

CAS Number: 1099592-35-4

Molecular Weight: 306.32

Formula: C18H14N2O3

Chemical Name: 2-hydroxy-N'-[(1E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide

Smiles: OC1=CC=CC=C1C(=O)N/N=C/C1=C2C=CC=CC2=CC=C1O

InChiKey: ZZSJOLDICPVVAV-YBFXNURJSA-N

InChi: InChI=1S/C18H14N2O3/c21-16-8-4-3-7-14(16)18(23)20-19-11-15-13-6-2-1-5-12(13)9-10-17(15)22/h1-11,21-22H,(H,20,23)/b19-11+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 62.5 mg/mL (204.03 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

NSAH depresses dGTP and dATP levels in the dNTP pool causing S-phase arrest, providing evidence for RR inhibition in cells. NSAH (0-10 μM, 2, 6, 24, or 72 h) exhibits potent anti-tumor activity in 3 cancer cell lines. NSAH blocks S-phase progression well to the extent and timing of the decreases in dATP and dGTP.

Products are for research use only. Not for human use.

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