Description
DHODH-IN-12 (Compound 12b) is a Leflunomide derivative and a weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07.
Product information
CAS Number: 1263303-93-0
Molecular Weight: 203.20
Formula: C10H9N3O2
Chemical Name: (E)-[(4-methylphenyl)carbamoyl]methanecarbonimidoyl cyanide
Smiles: CC1C=CC(=CC=1)NC(=O)/C(/C#N)=N/O
InChiKey: TUUSDSUFAQPEOW-UKTHLTGXSA-N
InChi: InChI=1S/C10H9N3O2/c1-7-2-4-8(5-3-7)12-10(14)9(6-11)13-15/h2-5,15H,1H3,(H,12,14)/b13-9+
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Designed a compound structurally related to Leflunomide, containing the furazan ring (Compound 12a), is designed. Compound 12a undergo ring 4 scission under physiological pH conditions to afford the corresponding cyano-oximes DHODH-IN-12 (Compound 12b). DHODH-IN-12 has been assayed as a DHODH inhibitor; its low potency is probably due to the unfavourable stereochemistry of the oxime substructure.
Products are for research use only. Not for human use.
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