Description
Raclopride-d5 (hydrochloride) is the deuterium labeled Raclopride. Raclopride is a dopamine D2/D3 receptor antagonist, which binds to D2 and D3 receptors with dissociation constants (Kis) of 1.8 nM and 3.5 nM, respectively, but has a very low affinity for D1 and D4 receptors with Kis of 18000 nM and 2400 nM, respectively.
Product information
CAS Number: 1217623-85-2
Molecular Weight: 388.73
Formula: C15H21Cl3N2O3
Chemical Name: 3,5-dichloro-N-{[(2S)-1-[(1,1,2,2,2-²H₅)ethyl]pyrrolidin-2-yl]methyl}-2-hydroxy-6-methoxybenzamide hydrochloride
Smiles: Cl.[2H]C([2H])([2H])C([2H])([2H])N1CCC[C@H]1CNC(=O)C1=C(O)C(Cl)=CC(Cl)=C1OC
InChiKey: ITLUETSTZABOFM-PODUPYNBSA-N
InChi: InChI=1S/C15H20Cl2N2O3.ClH/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2;/h7,9,20H,3-6,8H2,1-2H3,(H,18,21);1H/t9-;/m0./s1/i1D3,3D2;
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
Products are for research use only. Not for human use.
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