SPDP-C6-NHS ester


Catalog No. Size PriceQuantity
M32070-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

SPDP-C6-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

Product information

CAS Number: 158913-22-5

Molecular Weight: 425.52

Formula: C18H23N3O5S2

Chemical Name: 2,5-dioxopyrrolidin-1-yl 6-[3-(pyridin-2-yldisulfanyl)propanamido]hexanoate

Smiles: O=C(CCSSC1=CC=CC=N1)NCCCCCC(=O)ON1C(=O)CCC1=O

InChiKey: QYEAAMBIUQLHFQ-UHFFFAOYSA-N

InChi: InChI=1S/C18H23N3O5S2/c22-14(10-13-27-28-15-6-3-5-12-20-15)19-11-4-1-2-7-18(25)26-21-16(23)8-9-17(21)24/h3,5-6,12H,1-2,4,7-11,13H2,(H,19,22)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (235.01 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Products are for research use only. Not for human use.

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