Propargyl-PEG5-1-o-(b-cyanoethyl-n, n-diisopropyl)phosphoramidite


Catalog No. Size PriceQuantity
M32433-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Propargyl-PEG5-1-o-b-cyanoethyl-nn-diisopropylphosphoramidite is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Product information

CAS Number: 1682657-14-2

Molecular Weight: 432.49

Formula: C20H37N2O6P

Chemical Name: 5-[bis(propan-2-yl)amino]-4,6,9,12,15,18-hexaoxa-5-phosphahenicos-20-ynenitrile

Smiles: CC(C)N(C(C)C)P(OCCC#N)OCCOCCOCCOCCOCC#C

InChiKey: HEBYJWFLALAISI-UHFFFAOYSA-N

InChi: InChI=1S/C20H37N2O6P/c1-6-9-23-11-12-24-13-14-25-15-16-26-17-18-28-29(27-10-7-8-21)22(19(2)3)20(4)5/h1,19-20H,7,9-18H2,2-5H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Products are for research use only. Not for human use.

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